💊 Amlodipine (Amlodipine And Atorvastatin)
A combination tablet containing amlodipine, which lowers blood pressure and treats angina, and atorvastatin, which lowers cholesterol. It is prescribed for patients for whom treatment with both drugs is appropriate. It is taken orally once daily at a dose set by your doctor.
In Arabic: أملوديبين وأتورفاستاتين
✅ What it is used for
- Treatment of hypertension to lower blood pressure, reducing the risk of cardiovascular events such as strokes and myocardial infarctions
- Treatment of chronic stable angina and vasospastic angina (amlodipine component)
- Treatment of coronary artery disease (amlodipine component)
- Treatment of hyperlipidemia in patients for whom both drugs are appropriate (atorvastatin component)
🧪 Active ingredient
Amlodipine blocks calcium ion entry into vascular smooth muscle and cardiac muscle, dilating blood vessels, lowering blood pressure and relieving angina. Atorvastatin inhibits HMG-CoA reductase, the enzyme that drives cholesterol synthesis, lowering cholesterol levels.
🌿 Benefits
- Lowers blood pressure and reduces the risk of stroke and heart attack
- Relieves angina
- Lowers cholesterol
- Two medicines in one tablet taken once daily
📝 How to use
- Take the tablet by mouth once daily at any time of day, with or without food
- The dose is set by your doctor or pharmacist based on your condition and tolerance of each component; do not change it on your own
- Your doctor may check your cholesterol as early as 4 weeks after starting treatment and adjust the dose if needed
- Follow the dose prescribed for you and do not stop the medicine without consulting your doctor
💊 Dosage forms
- Film-coated oral tablets in several strength combinations: amlodipine (2.5, 5 or 10 mg) with atorvastatin (10, 20, 40 or 80 mg)
- Combinations with 2.5 mg or 5 mg amlodipine are white tablets; combinations with 10 mg amlodipine are blue tablets
⚠️ Common side effects
- Edema (swelling of ankles and feet), the most common amlodipine side effect, which is dose-related
- Dizziness
- Flushing
- Palpitations
- Fatigue
- Nausea
- Abdominal pain
- Somnolence
- Nasopharyngitis
- Joint pain (arthralgia)
- Diarrhea
- Pain in extremities
- Urinary tract infection
🚨 Serious — seek medical help
- Myopathy and rhabdomyolysis (unexplained muscle pain, tenderness or weakness, especially with malaise or fever), which may lead to acute kidney injury
- Immune-mediated necrotizing myopathy (rare)
- Hepatic dysfunction with elevated liver enzymes; rare fatal and non-fatal hepatic failure
- Angina or myocardial infarction on starting treatment or increasing the dose
- Symptomatic hypotension
- Severe hypersensitivity reactions, including anaphylaxis, angioneurotic edema, erythema multiforme, Stevens-Johnson syndrome and toxic epidermal necrolysis
- Increases in HbA1c and fasting serum glucose
⛔ Do not use if
- Acute liver failure or decompensated cirrhosis
- Hypersensitivity to amlodipine, atorvastatin or any excipient in the tablets
❗ Warnings & precautions
- Risk factors for myopathy: age 65 years or older, uncontrolled hypothyroidism, renal impairment, concomitant use of certain drugs, and higher doses
- Report unexplained muscle pain, tenderness or weakness promptly, especially with malaise or fever
- The medicine should be discontinued if CK levels are markedly elevated or myopathy is diagnosed or suspected
- Liver enzyme testing may be considered before starting and as clinically indicated afterward
- Angina or myocardial infarction may occur with initiation or dose increase
- Symptomatic hypotension is possible, particularly in patients with severe aortic stenosis
- Temporary discontinuation may be needed in acute or serious conditions at high risk of renal failure secondary to rhabdomyolysis
🔄 Drug interactions
- CYP3A inhibitors (moderate and strong): increase amlodipine exposure and may require dose reduction; monitor for hypotension and edema
- CYP3A inducers: monitor blood pressure closely
- Sildenafil: monitor for hypotension when given with amlodipine
- Cyclosporine and tacrolimus: amlodipine may increase their systemic exposure
- Certain drugs and grapefruit juice that increase the risk of myopathy and rhabdomyolysis (consult your doctor)
- Rifampin: may reduce atorvastatin plasma concentrations; administer simultaneously with atorvastatin
- Oral contraceptives: may increase plasma levels of norethindrone and ethinyl estradiol
- Digoxin: may increase digoxin plasma levels; monitor patients appropriately
- Tell your doctor or pharmacist about all medicines and supplements you use
🤰 Pregnancy
Atorvastatin may cause fetal harm based on its mechanism of action; it should be discontinued when pregnancy is recognized, or the patient's ongoing therapeutic needs should be considered. Available amlodipine data in pregnancy are insufficient to determine drug-associated risk. Consult your doctor before use.
🍼 Breastfeeding
Breastfeeding is not recommended during treatment with amlodipine and atorvastatin tablets.
🧒 Children
Safety and effectiveness of the combination tablets have not been established in pediatric patients. Amlodipine (2.5 to 5 mg daily) lowers blood pressure in patients 6 to 17 years, and atorvastatin is established for pediatric patients 10 years and older with HeFH and HoFH, under medical supervision.
👴 Older adults
Safety and effectiveness of the combination have not been established in geriatric patients. Age 65 or older is a risk factor for myopathy, and amlodipine clearance is decreased (AUC increased about 40-60%), so a lower initial dose may be required. Dose selection should be cautious with monitoring.
🌡️ Storage
Store at 25°C (77°F); excursions permitted to 15°C-30°C (59°F-86°F) (USP Controlled Room Temperature).
⏰ Missed dose
The US label text provided does not give specific instructions for a missed dose. Ask your doctor or pharmacist.
🆘 Overdose
There is no information on overdosage with the combination tablets in humans. Amlodipine overdose may cause excessive peripheral vasodilation with marked hypotension and possibly reflex tachycardia. No specific antidote for atorvastatin is known. In case of overdose, seek emergency medical help or contact Poison Control (1-800-222-1222) immediately.
💰 Price & brands in your area
Locally made brands: Vascopin 5 (tablet) (Jerusalem Pharmaceuticals)، Amlodipine (single-agent; brand name not shown in snippet) (Birzeit Pharmaceutical)، Valzadepine 160/10 (valsartan + amlodipine) (Pharmacare)، Valzadepine HCT 160/10/12.5 (valsartan + amlodipine + hydrochlorothiazide) (Pharmacare)
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Mechanism of action
Amlodipine is a dihydropyridine calcium channel blocker that inhibits transmembrane calcium influx into vascular smooth muscle and cardiac muscle, with a greater effect on vascular smooth muscle, acting as a peripheral arterial vasodilator to reduce peripheral vascular resistance and blood pressure and relieve angina. Atorvastatin is a selective, competitive inhibitor of HMG-CoA reductase, the rate-limiting enzyme in cholesterol biosynthesis.
Labeled dosing
Taken orally once daily at any time of day, with or without food; dosage is individualized on effectiveness and tolerance of each component. Adult amlodipine: usual start 5 mg, maximum 10 mg daily (2.5 mg in small, fragile or elderly patients or hepatic insufficiency); angina 5-10 mg; CAD 5-10 mg. Adult atorvastatin: usual start 10-20 mg, range 10-80 mg daily; patients needing LDL-C reduction > 45% may start at 40 mg. The dose is set by the doctor or pharmacist.
- Tablets may be substituted for individually titrated components or used as additional therapy for patients already on one component
- May be used to initiate treatment in patients with hyperlipidemia and either hypertension or angina
- In general, wait 7 to 14 days between amlodipine titration steps
- Assess LDL-C as early as 4 weeks after initiating atorvastatin and adjust dosage if necessary
- Atorvastatin may cause fetal harm based on its mechanism; discontinue when pregnancy is recognized or consider the patient's ongoing therapeutic needs
🎓 Key points for students
- Amlodipine: dihydropyridine calcium channel blocker and peripheral arterial vasodilator
- Atorvastatin: statin that inhibits HMG-CoA reductase (rate-limiting enzyme of cholesterol synthesis)
- Edema is the most common amlodipine adverse reaction and is dose-related
- Key statin risks: myopathy, rhabdomyolysis and hepatic dysfunction
- CYP3A inhibitors increase amlodipine exposure and may require dose reduction
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Why combine amlodipine and atorvastatin in one tablet?
It treats high blood pressure or angina together with high cholesterol in patients who need both drugs, with one daily dose.
Should I take it with food?
It can be taken once daily at any time of day, with or without food.
Which symptoms need urgent medical attention?
Unexplained muscle pain, tenderness or weakness (especially with malaise or fever), signs of severe allergy, or liver problem symptoms such as jaundice.
Can it be used in pregnancy or breastfeeding?
Atorvastatin may cause fetal harm and breastfeeding is not recommended during treatment. Consult your doctor before use.
Can I adjust the dose myself?
No. Your doctor or pharmacist determines the dose based on your condition, response and tolerance.
⚕️ For education only — not a substitute for advice from your doctor or pharmacist. Do not start or stop any medicine without advice. Source: official FDA drug label via openFDA (2026-05), simplified. Updated: 2026-11-10.