💊 Desloratadine (Desloratadine Oral Solution)
Desloratadine oral solution is used to relieve symptoms of seasonal and perennial allergic rhinitis and chronic idiopathic urticaria. It works by blocking histamine H1 receptors. The dose depends on age and must be set by your doctor or pharmacist.
In Arabic: ديسلوراتادين
🏷️ Brand names & manufacturers
Packages shown are US-market (DailyMed). Brands available in Palestine are in the price section below.
Clarinex🏭 Organon LLC
Desloratadine Oral Solution🏭 INA Pharmaceutics, Inc.
Desloratadine🏭 Virtus Pharmaceuticals, LLC
Desloratadine🏭 Morepen Bio Inc.
Desloratadine🏭 Lupin Pharmaceuticals, Inc.✅ What it is used for
- Relief of nasal and non-nasal symptoms of seasonal allergic rhinitis in patients 2 years and older
- Relief of nasal and non-nasal symptoms of perennial allergic rhinitis in patients 6 months and older
- Relief of itching and reduction in the number and size of hives in chronic idiopathic urticaria in patients 6 months and older
🧪 Active ingredient
The active ingredient is desloratadine, a long-acting tricyclic histamine antagonist with selective H1-receptor antagonist activity. It also inhibited histamine release from human mast cells in vitro.
🌿 Benefits
- Relieves nasal and other allergy symptoms of allergic rhinitis
- Relieves itching and reduces hives in chronic urticaria
- Once-daily dosing
- Can be taken with or without food
📝 How to use
- Take the solution by mouth once daily, with or without food
- The age-appropriate dose is determined by your doctor or pharmacist
- Use a commercially available measuring dropper or syringe calibrated to deliver 2 mL and 2.5 mL; do not use a household spoon
- Protect from light as described under storage
💊 Dosage forms
- Oral solution 0.5 mg/mL (118 mL bottle), clear, colorless to slightly yellow, with a bubble gum odor
⚠️ Common side effects
- Pharyngitis (sore throat)
- Dry mouth
- Myalgia (muscle pain)
- Fatigue
- Somnolence (sleepiness)
- Dysmenorrhea
- Headache, nausea, dizziness, and dyspepsia (in chronic urticaria patients)
🚨 Serious — seek medical help
- Hypersensitivity reactions: rash, pruritus, urticaria, edema, dyspnea, and anaphylaxis (stop the drug at once and seek medical help)
⛔ Do not use if
- Hypersensitivity to desloratadine, to any ingredient of the product, or to loratadine
❗ Warnings & precautions
- Stop the drug at once and consider alternative treatment if rash, itching, hives, swelling, or difficulty breathing occurs
- Dosage adjustment is recommended in renal and hepatic impairment; no dosing recommendation can be made for children with liver or renal impairment due to lack of data
- Safety and effectiveness of the oral solution have not been demonstrated in patients under 6 months of age
- Do not self-medicate; consult a doctor or pharmacist
🔄 Drug interactions
- Ketoconazole, erythromycin, azithromycin: increased desloratadine plasma levels, with no clinically relevant change in safety profile
- Fluoxetine: increased desloratadine plasma levels, with no clinically relevant change in safety profile
- Cimetidine: increased desloratadine plasma levels, with no clinically relevant change in safety profile
- Tell your doctor or pharmacist about all medicines you take
🤰 Pregnancy
Limited data in pregnant women are not sufficient to inform the risk of major birth defects or miscarriage, and there are no adequate and well-controlled studies in pregnant women. Animal studies did not show teratogenicity. Consult your doctor before use.
🍼 Breastfeeding
The provided label text does not include information on breastfeeding; consult your doctor before use.
🧒 Children
Safety of the oral solution was established in 246 pediatric subjects aged 6 months to 11 years in three placebo-controlled studies. Safety and effectiveness have not been demonstrated in patients under 6 months of age. The dose is set by age by the doctor.
👴 Older adults
Clinical studies did not include enough subjects aged 65 and over to determine whether they respond differently. Dose selection for the elderly should be cautious, reflecting the greater frequency of decreased hepatic, renal, or cardiac function and of concomitant disease or drug therapy.
🌡️ Storage
Store at 20° to 25°C (68° to 77°F). Protect from light.
⏰ Missed dose
The provided label text gives no instructions on missed doses; ask your doctor or pharmacist.
🆘 Overdose
In overdose, consider standard measures to remove unabsorbed drug and give symptomatic and supportive treatment. Desloratadine and 3-hydroxydesloratadine are not eliminated by hemodialysis. Somnolence was reported at 10 mg and 20 mg/day. Seek medical help immediately.
💰 Price & brands in your area
🏛️ Official price in Palestine — Ministry of Health price list:
| Product | Company | Pack | Price |
|---|---|---|---|
| RINAZAL SYRUP DESLORATADINE | BPC | SYRUP | 15 ₪ |
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Mechanism of action
Long-acting tricyclic histamine antagonist with selective H1-receptor antagonist activity; inhibited histamine release from human mast cells in vitro; did not readily cross the blood-brain barrier in animal studies (clinical significance unknown). Antihistaminic effect appears by 1 hour and may persist up to 24 hours.
Labeled dosing
Dose is set by the doctor/pharmacist. Per label, once daily: adults and adolescents ≥12 years 5 mg (10 mL); children 6–11 years 2.5 mg (5 mL); 12 months–5 years 1.25 mg (2.5 mL); 6–11 months 1 mg (2 mL). May be taken without regard to meals.
- Dosage adjustment is recommended in renal and hepatic impairment
- No dosing recommendation can be made for children with hepatic or renal impairment due to lack of data
- Not removed by hemodialysis
- 45 mg daily for 10 days produced no clinically relevant adverse events; heart rate rose 9.2 bpm and QTc (Bazett) 8.1 msec vs placebo
🎓 Key points for students
- Class: histamine H1-receptor antagonists
- Mechanism: selective long-acting H1 antagonist
- Tmax ~3 hours after 5 mg tablet; steady-state Cmax 4 ng/mL
- Contraindication: hypersensitivity to desloratadine or loratadine
- Interactions: CYP3A4 inhibitors, fluoxetine, cimetidine raise levels without clinically relevant safety change
- Most common adult adverse events: pharyngitis and dry mouth
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What is desloratadine used for?
It relieves symptoms of seasonal and perennial allergic rhinitis and chronic idiopathic urticaria in the age groups listed.
Can it be taken with food?
Yes, it can be taken with or without food.
How often is it taken?
Once daily; the age-appropriate dose is set by your doctor or pharmacist.
What are the common side effects?
Sore throat, dry mouth, muscle pain, fatigue, sleepiness, and painful periods.
When should I stop it?
Stop and seek medical help if you develop signs of hypersensitivity such as rash, itching, swelling, or trouble breathing.
Is it suitable for infants?
It is used from 6 months of age for perennial allergic rhinitis and chronic urticaria; safety is not established under 6 months.
⚕️ For education only — not a substitute for advice from your doctor or pharmacist. Do not start or stop any medicine without advice. Source: official FDA drug label via openFDA (2025-10), simplified. Updated: 2026-11-10.