💊 Ceftriaxone (Ceftriaxone And Dextrose)

🏷️ Brand names & manufacturers

Ceftriaxone And Dextrose🏭 B. Braun Medical Inc.DailyMed

Ceftriaxone🏭 Hikma Pharmaceuticals USA Inc.DailyMed

Ceftriaxone🏭 Sagent PharmaceuticalsDailyMed

Ceftriaxone🏭 WG Critical Care, LLCDailyMed

✅ What it is used for

• Lower respiratory tract infections
• Skin and skin structure infections
• Complicated and uncomplicated urinary tract infections
• Pelvic inflammatory disease
• Bacterial septicemia
• Bone and joint infections
• Intra-abdominal infections
• Meningitis
• Surgical prophylaxis

🧪 Active ingredient

The active ingredient is ceftriaxone sodium, a sterile, semisynthetic, broad-spectrum cephalosporin antibacterial given intravenously to treat bacterial infections.

🌿 Benefits

• Treats bacterial infections caused by susceptible organisms in multiple body systems
• Helps prevent infection when given before surgery

📝 How to use

• This product is for intravenous use only, infused over approximately 30 minutes.
• It is given by a healthcare professional, not self-administered.
• The dose and duration are set by the doctor or pharmacist according to the infection and the patient's condition.
• This dual-chamber container is for patients who require the entire 1 g or 2 g dose and not any fraction thereof.

💊 Dosage forms

• DUPLEX dual-chamber single-dose container: 1 g ceftriaxone for injection with 50 mL of 3.74% dextrose injection
• DUPLEX dual-chamber single-dose container: 2 g ceftriaxone for injection with 50 mL of 2.22% dextrose injection

🔄 Drug interactions

• Vancomycin, amsacrine, aminoglycosides, and fluconazole: physically incompatible with ceftriaxone in admixtures.
• Calcium-containing products: precipitation can occur; do not administer simultaneously with calcium-containing IV solutions, but they may be given sequentially.

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👨‍⚕️ For healthcare professionals

Mechanism of action

Ceftriaxone is an antibacterial drug of the cephalosporin class.

Labeled dosing

General adult dosing per the label: 1 g to 2 g once a day or in equally divided doses every 12 hours, not exceeding 4 g/day, given IV over approximately 30 minutes. Surgical prophylaxis: 1 g IV once, 1/2 to 2 hours before surgery. Usual duration is 4 to 14 days, longer in complicated infections; at least 10 days for Streptococcus pyogenes. No more than 2 g/day in hepatic impairment with significant renal impairment. The final dose is set by the doctor or pharmacist.

• The DUPLEX container is for use only when the entire 1 g or 2 g dose is required, not any fraction.
• Inspect visually; use only if the solution is clear and container and seals are intact.
• Do not use plastic containers in series connections; avoid air embolism.
• Do not introduce additives into the container.
• Not for pediatric patients requiring less than the full adult dose.

🎓 Key points for students

• Ceftriaxone: semisynthetic broad-spectrum cephalosporin given IV.
• Contraindication: history of anaphylaxis to ceftriaxone, cephalosporins, penicillins, or other beta-lactams.
• Cross-hypersensitivity with penicillin allergy may occur in up to 10%.
• Do not give simultaneously with calcium-containing IV solutions (precipitation).
• Key warnings: C. difficile-associated diarrhea, neurological reactions, hemolytic anemia.
• Most common adverse reactions (>2%): diarrhea, eosinophilia, thrombocytosis, leukopenia, elevated SGOT/SGPT.
• Overdose is not reduced by hemodialysis or peritoneal dialysis.